ACCUTE APPENDICITIS AND PREGNANCY: CLINICAL COURSE, DIAGNOSTICS AND TREATMENT

Khvorostukhina Nataliya Fedorovna, Candidate of medical science, associate professor, sub-department of obstetrics and gynecology, Saratov State Medical University named after V. I. Razumovsky (Saratov, 112 Kazachya Bolshaya str.), Khvorostukhina-NF@yandex.ru
Rogozhina Irina Evgen'evna, Candidate of medical science, associate professor, head of sub-department of obstetrics and gynecology, Saratov State Medical University named after V. I. Razumovsky (Saratov, 112 Kazachya Bolshaya str.), kafed-ra@yandex.ru
Stolyarova Ul'yana Vladimirovna, Candidate of medical science, assistant, sub-department of obstetrics and gynecology, Saratov State Medical University named after V. I. Razumovsky (Saratov, 112 Kazachya Bolshaya str.), stolyarova.ulyana@yandex.ru

616.346.2-002.1-055.26-07-08(045)

Results of inspection and treatment of 154 patients with an acute appendicitis are presented, of them the main group was made by 98 pregnant women at gestatsiya terms from 4 to 37 weeks. We prove that the atypical clinical presentation of appendicitis in pregnancy is caused by insufficient production of proand antiinflammatory cytokine expressed by endotoxemia. Imbalance of cytokines, Th1-reduction function and Th2-lymphocytes and as a consequence, inhibition of apoptosis contribute to the development of more destructive forms of appendicitis (80%), increasing the risk of complications in the postoperative period of gestation. An algorithm for diagnostic measures in pregnant women with suspected acute appendicitis, which allows to reduce the time of diagnosis and providing medical assistance to such patients.

appendicitis, pregnancy, indicators of endointoxication, cytokines.

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